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Table?1. Baseline demographics of recruited subjects Figure?1 shows the trajectory of the TUG, BI and EQ-5D results prior to death or the end of the study. There was a steady increase in TUG scores in both patient groups, with a larger increase observed in the group that died. There was a significant increase in TUG scores over the 6 months prior to death 2.24 [95% confidence interval (CI) 1.16�C4.32], P = 0.017. For the BI there were no significant changes over time; full results are shown in the Supplementary data. When the changes over time of the variables measured were compared there was a moderately strong and statistically significant inverse correlation between log TUG and BI (P Azastene Scatter plot of the overall change in the TUG score versus the change selleckchem in BI for patients with more than one measurement (n = 35). Multivariable analysis suggested an increase in the TUG score and a decrease in the BI following a sentinel event; however, this failed to reach significance (Supplementary data). There was a significant association of serum albumin with the TUG score [0.90 (95% CI 0.84�C0.97), P = 0.005] and BI [1.80 (95% CI 0.19�C3.42), P = 0.029]. The only significant associations with mortality were serum albumin hazard ratio [HR] 0.81 (95% CI 0.67�C0.97), P = 0.024 and male gender [HR 5.94 (95% CI 1.50�C23.5), P = 0.011], both of which were associated with an increased risk of mortality. Male gender was associated with an approximately 6-fold increased risk of mortality. Each decrease of 1 g/dL of serum albumin was associated with a 19% increased risk of death (95% CI 3�C33%) (Table?2). Table?2. Multivariable analysis of the TUG score There was also a significant decrease in the EQ-5D over the 6 months prior to death [?0.19 (95% CI ?0.33 to ?0.06), P = 0.006], however, there was no trend in the EQ-5D over the study period in patients who remained Pictilisib alive (Figure?1). The EQ-5D has five dimensions. In a post hoc analysis we explored the relationship between the mobility dimension of the EQ-5D, which is patient-reported, the TUG, which is investigator measured, and serum albumin. The results are shown in Figure?3 and suggest that both serum albumin and TUG were associated with EQ-5D patient-reported mobility. Fig.?3. Relationship between EQ-5D mobility, TUG score and serum albumin (g/dL). There was no relationship between eGFR, SCG, haemoglobin and mortality or TUG, BI and EQ-5D (see Supplementary data). Discussion The primary objective of this study was to observationally define the trajectory of the functional status of patients with advanced renal disease who choose not to dialyse. We have shown that the TUG score increased while the EQ-5D decreased in the last 6 months of life.