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Treatment modalities for BP lowering in the standard SBP reduction group were unlimited at the discretion of the responsible physicians until the recommended target SBP of Selleck ZD6474 in standard SBP reduction group was oral (including nasogastric if required) and/or transdermal routes. In the event of failure of first line medication, IV treatment was started to reach target SBP of result in high variability in BP10 and may predispose to hematoma expansion.11 IV nicardipine-treated ICH and SAH patients had less BP variability, and fewer dosage adjustments compared with IV labetalol or IV nitroprusside-treated patients in previous studies.12,13 Hydralazine, nitroglycerin, and niroprusside were used in 460 of 1,399 (33%) subjects and 137 of 1,430 (10%) in subjects randomized to intensive and standard SBP reduction in INTERACT II, respectively. More patients in the intensive-treatment group TRIB1 than in the standard-treatment group received two or more IV agents to lower their blood pressure (26.6% versus 8.1%, p of the agents14 suggested that IV hydralazine and nitroprusside can increase both regional cerebral blood flow (rCBF) and intracranial pressure (ICP).15�C17 Nitropaste, nitroglycerine, and nicardipine can increase rCBF without any clear increase in ICP.14 It has also been shown that labetalol, hydralazine, and enalaprilat do not affect rCBF in acute ICH patients.18 It remains unclear whether cerebrovascular effects of various antihypertensive agents could have impact on clinical outcomes because of the diverse therapeutic approaches in the INTRERACT II. In one observational study, after adjustment for baseline risk of mortality, the risk of in-hospital mortality was higher among ICH patients treated with nitroprusside compared with nicardipine ON-1910 (OR 1.7, 95% CI 1.3�C2.2).19 Intensive SBP reduction post-24 hours after randomization In INTERACT II, for participants assigned to receive intensive treatment, the goal was to achieve a SBP level of