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Among the Gram-positive bacteria recovered, 79% were methicillin-resistant S.?aureus [97]. Another study, conducted in a teaching hospital in Tabriz, north-western Iran, reported that 63% of Acinetobacter baumannii isolates collected from various clinical specimens were resistant to carbapenems, the antibiotics that are considered to be the last available line of defence against many Gram-negative bacteria [96,98]. Another study, in Ahwaz, south-western Iran, revealed that 38% of P.?aeruginosa strains isolated from 100 burns patients were multidrug-resistant; 41% of the isolates were resistant to carbapenems [99]. There also reports of multidrug-resistant Salmonella spp. [56]. Islam is the prevailing religion in Iran. Every year, a large number of people from Iran go to Saudi Arabia to take part thiram in the Hajj ritual, which is another important issue to be considered in the control of infectious diseases. In mass gatherings such as the Hajj, antibiotic-resistant strains can easily be spread to the region or other continents by international travellers. Every year after the return of pilgrims from the Hajj, physicians in Iran face several new infectious diseases��mainly flu-like syndromes [96,100]. All authors declare no potential check details conflict of interest. ""Chromosomes in a young one-cell embryo are generally aligned at the metaphase plate (upper embryo), but this process can easily be disrupted. Inhibition of Polo-like kinase 1 activity with BI 2536, for example, results in a disorganized spindle (lower embryo). This phenotype is also associated with an absence of ��-Tubulin (green) from the spindles, marked by ��-tubulin (red), with misplaced condensed chromosomes (blue). Baran et al. (this issue) hypothesize that Plk1 activity is not essential Erastin manufacturer for the entry to first mitosis, but is required for the events leading up to metaphase-anaphase transition in one-cell mouse embryo. ""Few studies have examined the epidemiology of respiratory viral infections in large tertiary centres over more than one season in the era of molecular diagnosis. Respiratory clinical specimens received between 1 January 2011 and 31 December 2012 were analysed. Respiratory virus testing was performed using a large panel of real-time PCR or RT-PCR. Results were analysed according to sample type (upper versus lower respiratory tract) and age group. In all, 2996 (2469 (82.4%) upper; 527 (17.6%) lower) specimens were analysed. Overall positivity rate was 47.4% and 23.7% for upper and lower respiratory samples, respectively. The highest positivity rate was observed in patients under 18?years old (p?