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05; aINS: P = 0.064), and particularly the AFL condition (vACC: P differential brain activity to congruent versus incongruent social feedback in the vACC, left amygdala/hippocampus and bilateral posterior hippocampus, right anterior insula/inferior frontal gyrus (aINS), right www.selleckchem.com/products/ve-822.html caudate, and left middle occipital gyrus (see Fig. ?Fig.5A,5A, B, C and Fig. ?Fig.6A,6A, B, C). In other words, in the above regions, increasing attachment avoidance scores were linked with a shift in processing from incongruent to congruent social feedback. The putative underlying mechanisms of this shift, however, differed considerably. In the amygdala/hippocampus and caudate, attachment avoidance appeared to be particularly associated with a decrease in activity during incongruent social feedback processing (multiple regression analysis; amygdala/hippocampus: P change to congruent social feedback, although this effect FMO4 did not reach significance (multiple regression analysis; vACC: P = 0.098; aINS: P = 0.16), and mainly driven by increased BOLD signal change to the AFL condition (vACC: P Sotrastaurin manufacturer anatomical T1 template at a statistical threshold of P