Historically, the first person to link IOP to the glaucoma was the English ophthalmologist, Richard Bannister, who described the phenomenon

In open angle glaucoma (OAG) the drainage pathway seems normal and in angle-closure glaucoma (ACG) the drainage pathway is obstructed. The pathogenesis of glaucoma is multifactorial. Nonetheless, the intra ocular stress (IOP) is the most evident chance factor for glaucomatous damage and to date IOP lowering medications continue to be the only clinically validated treatment method of glaucoma [4,five]. Traditionally, the 1st person to link IOP to the glaucoma was the English ophthalmologist, Richard Bannister, who explained the phenomenon in 1622[6]. In1862 it was identified that the extract from the calabar bean could counteract mydriasis, and in 1876 pilocarpin was launched. The development of force decreasing medication accelerated in 1978 with the acceptance of Timolol[six]. In addition to glaucoma medication, glaucoma surgical procedure has been executed since 1856 when Albrecht von Graefe released iridectomy. Hundred a long time later the most frequent glaucoma surgical method, trabeculectomy, was developed[seven,8]. In spite of the growth of far more surgical methods the considerably most predominant treatment of glaucoma is force lowering eye drops. The prevalence of glaucoma has been reported in several studies and considerable ethnic and geographic variations have been discovered. In spite of the special probability to estimate the prevalence of glaucoma in the entire populace in Denmark only a couple of epidemiologic scientific studies have been executed. To our expertise the initial research to estimate the number of glaucoma individuals in Denmark was done in 1989. This review was based mostly on a national usage of anti-glaucomatous medication and exposed a prevalence of .76% in the age team earlier mentioned 40 a long time [nine]. A comply with up of this research was carried out in 2000 primarily based on a questionnaire survey amid non-public exercise ophthalmologists in Denmark. In this examine the prevalence in Denmark was estimated to .65% in the complete population[10]. A latest research focused on the yearly charges of glaucoma in Denmark and unveiled an incidence price of one.two for each a thousand grownups in the interval from 2002 to 2007[11]. To our information no previous research has benefited from a total info sample from an whole inhabitants to estimate the incidence and prevalence of glaucoma. Therefore, the goal of the examine was to explain the incidence and prevalence of glaucoma in the Danish inhabitants throughout a fifteen-yr period of time. In addition, we wished to investigate the geographic variation of glaucoma in Denmark and characterize the utilization pattern of glaucoma treatment in the aforementioned interval.The research populace comprised all men and women living in Denmark in the interval from 1996 to 2011. The authorities financed healthcare method requests all pharmacies in Denmark to sign-up all prescriptions at an person level by the so-known as CPR-quantity. Furthermore, the Danish National Registry of Individuals has gathered discharge diagnoses from community and personal hospitals in Denmark because 1977. From 1995 the registry has utilised diagnoses as coded in the ICD-10. Data on glaucoma treatment was received from the Danish Registry of Medicinal Item Stats. Adhering to prescriptions had been regarded as glaucoma medicine (ATCcodes: S01ED01-05 = -blockers S01EE = prostaglandin analogs S01EA = two-adrenergic agonists, S01EB = parasympathomimetic medication, S01EC = carbon anhydrase inhibitors S01EA51, S01EB51, S01ED51 = set combination drugs). Glaucoma was described as a dysfunction treated as glaucoma. Sufferers were labeled as "incident" by the time of their first prescription of glaucoma medicine. Sufferers had been categorized according to their amount of remedy changes. A remedy adjust was defined as the start off of a glaucoma treatment with a lot more than one hundred eighty-working day time-clever gap among two purchases of glaucoma drugs.Incidence rates have been calculated in 10-year age strata. As formerly mentioned, clients have been labeled as "incident" by the time of their very first prescription of glaucoma treatment.