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Assays Blood serum and plasma were tested. The serum was separated from venous blood by centrifugation at 3,000�� g for 20 minutes and stored at ?70��C. The blood levels of inflammation markers (fibrinogen, interleukin [IL]-6, IL-8, IL-12, tumor necrosis Selleck Imatinib factor [TNF]-��, high-sensitivity C-reactive protein [hsCRP], and sCD40L) were measured at days 10�C14, with further follow up at year 1, to determine the clinical significance of inflammation markers in predicting cardiovascular events after PCI. Cytokine Quantikine? (R&D Systems, Inc., Minneapolis, MN, USA) tests were used for: human IL-6 (sensitivity =0.16 ng/mL; intra- and interassay precision, coefficients of variation [CV] =5.7 and 8.2%), human IL-8 (sensitivity =0.011 ng/mL, intra- and interassay precision; CV =4.4 and 7.3%), human IL-12 (sensitivity =0.011 ng/mL, intra- and interassay precision; CV =4.4 and 7.3%), click here human TNF-�� (sensitivity =9.0 pg/mL, intra- and interassay precision; CV =4.5 and 7.0%), and sCD40L (sensitivity =0.12 ng/mL, intra- and interassay precision; CV =6.4 and 11.4%). hsCRP was analyzed by means of solid-phase enzyme immunoassay (EIA), using a BioMedica kit (Waterloo, NSW, Australia) (sensitivity =0.12 ng/mL, intra- and interassay precision; CV =6.1 and 9.4%). The risk of death or myocardial infarction in patients assessed by TIMI Risk Score.17 Statistical analysis The data were statistically processed using SPSS Statistics for Windows, Version 21.0 (IBM Corp, Armonk, NY, USA) software. The Shapiro-Wilk test was used to assess the normality of continuous data. Most of the data had statistically significant deviations from the normal distribution; therefore, Me (Q1;Q3) was used where Me was the median, and 25%�C75% was the interquartile range that comprised 50% of the data on both sides of the median. The nonparametric Mann�CWhitney U-test was used to test the hypothesized differences between the samples. The differences between the categorical variables in the mismatched samples were analyzed using Oxymatrine ��2 test, with Yates�� correction for continuity. The frequency of the properties in the groups was analyzed by means of the odds ratio calculation. P