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Statistical analysis The descriptive statistics are expressed as frequencies and percentages for categorical variables and as means and standard deviations (SD) for continuous variables. However, the duration of stays in the unit and the numbers of dyspnea episodes are expressed as medians and interquartile ranges (IQRs), due to the asymmetric nature of their distributions. We used chi-squared tests, Student's t tests, and Mann�CWhitney U-tests for group comparisons, depending on the type of variable (qualitative, quantitative and ordinal, respectively). AP24534 cell line Contingency tables were used to estimate the crude relative risk or odds ratio (with a 95% confidence interval) for the occurrence of dyspnea. The threshold of significance was fixed at P?=?0.05 for two-tailed tests. We then carried out multivariate logistic regression analysis, with three explanatory variables for dyspnea (the site of the primary cancer, the presence of lung metastases and the site x lung metastasis interaction), to take into account the possible differential effects of metastases as a function of the site of origin. A second logistic regression analysis focused on the time of dyspnea onset, distinguishing between ETDs and more precocious episodes of dyspnea. Statistical analyses were carried out with XLSTat (version 5.01; Addinsoft, Paris, France) and R (http://www.r-project.org). Results STI571 concentration During the last 6?years, there were 6455 recorded stays in the PCH, corresponding to 6119 patients (92% with cancer): 242 patients had two stays in the PCH and 46 had three or more stays in the PCH. All the patients had a Karnovsky index of 40% or less and none of the cancer patients received chemotherapy or radiotherapy during their stay in the hospital. By performing queries (BO) on the 114,294 medical observations (0.8/patient per day) and 696,437 notes added by paramedical staff (4.8/patient per day), we identified 13,282 episodes of dyspnea occurring during 2608 stays in the hospital (5.1 episodes of dyspnea per stay). There was at least one episode of dyspnea during 40% of the stays in the hospital (Table?(Table1).1). Age, sex and having several UNC2881 stays in the PCH were not risk factors for the occurrence of dyspnea (Table?(Table1).1). The occurrence of dyspnea was linked to longer stays in the PCH: the median duration of PCH stay increased from 11 (4�C24) to 17 (7�C33) in patients experiencing dyspnea (P?