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Each question has a 5-point scale, where 0 means an absence of symptoms and 4 represents severe symptoms. In the Five Facet Mindfulness Questionnaire (FFMQ) of 39 items, five domains of mindfulness ��skills�� are assessed: observing, describing, acting with awareness, nonjudging see more of inner experience, and nonreactivity to inner experience [12]. Adding up the domains results in a total score of an approximation of mindfulness ��skills.�� Items are rated on a 5-point Likert-type scale from ��never or very rarely true�� to ��very often or always true.�� The subscales of the Dutch FFMQ have been shown to have good internal consistencies. The PDQ-39 is a subjective questionnaire to assess QoL in patients with PD [13]. The questionnaire consists of thirty-nine questions, which are divided into eight subscales (mobility, ADL, emotional well-being, stigma, social support, cognition, communication, and bodily discomfort). Each question has a range from 0 (no problem) to 100 (continuous problem/unable to do it). The Beck Depression Inventory (BDI) is a questionnaire Aldosterone to evaluate the severity of depressive mood states. It scores components like hopelessness and guilt feelings, as well as fatigue and other physical symptoms. It consists of 21 questions, rated between 0 (no symptom impact) and 3 (maximum symptom impact) with a maximum score of 63 [14]. All participant-reported outcome measures were entered into a database by personnel blinded to group assignment. All investigator rated scales were administered by a blinded assessor. Standard protocol approvals, registration, and patient consent forms were approved by the Institutional Review Board of the Antwerp University Hospital, Antwerp, Belgium. The study was registered at ClinicalTrials.gov (#NCT01607697). All participants gave written informed consent. 2.4. Statistical Analysis A repeated measures ANOVA with as within subjects variable the questionnaires and between subjects variable the group (Mindfulness Based Intervention Group vs Usual Care Group) was carried out on data obtained from the questionnaires completed at baseline and after 8-week follow-up. www.selleckchem.com/screening/natural-product-library.html Attendance to the training sessions and amount of home practice time were recorded. 3. Results Significant change was obtained for the UPDRS motor III score (F = 4.39, p