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7. Conclusion NLPHL remains a relatively rare disease with a good overall prognosis among both children and adults. In this paper, we report the case of a 3-year-old boy with newly diagnosed NLPHL (to our knowledge, the youngest case ever reported in the literature) who achieved complete remission of his Stage IIa disease with combined cytotoxic chemotherapy and the anti-CD20 antibody rituximab. The outcome of this case supports the use of rituximab with traditional chemotherapy regimens as first-line, upfront therapy GDC-0449 order for NLPHL��though prospective studies are needed to confirm the added benefit of this combined-treatment approach. The prognosis and clinical significance of IgD-positive disease are another area that warrants further investigation. Answering these clinical questions will take a concerted effort and cooperation of multiple centers given the relatively low incidence of NLPHL. Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper.The current MS-275 era of novel therapeutics has enabled groundbreaking consequences in the world of medicine as survivorship rates from life-threatening conditions are improving. The implantation of left ventricular assistant devices (LVAD) is one such trailblazing treatment modality for heart failure. The LVAD has emerged as a bridge to transplantation until a donor heart is available as well as destination therapy in patients unfit for cardiac transplantation. This has significantly alleviated the mortality risks related to heart failure [1]. Advanced heart failure requires careful attention to fluid balance and treatments with any potential cardiac toxicity may lead to decompensation and death. Unique challenges may further Quinapyramine arise in case of a new cancer diagnosis preceding the LVAD implant. We present a case of limited-stage small cell lung cancer (SCLC) of the lung in a patient with an LVAD, undergoing evaluation for cough while under consideration for cardiac transplantation. This paper aims to discuss the optimal management options for SCLC in light of the comorbidities present. 2. Case Presentation We report a 57-year-old male with history of extensive prior tobacco use, nonischemic cardiomyopathy, and an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 3. After successfully completing his initial evaluation, he was deemed cancer-free and eligible for cardiac transplantation. Due to severe heart failure despite standard medications, he received mechanical cardiac support with an LVAD. Three months after surgery for the LVAD, he was noted to have mediastinal widening on a chest X-ray performed for dyspnea and cough.