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Statistical analysis Repeated measure analysis of variance (ANOVA) was used for data analysis. Post-hoc analysis (Tukey-test) was performed for assessing specific inter-group variations. Differences with P and alanine amino transaminase levels. Table 1 Liver biochemistries from BDL and sham-operated rats 21 days Passive avoidance learning test The latencies were measured in prefoot shock (IL), as well as 7 and 21 days postfoot shock (retention time or STL). Decrement of the latency (shorter PCI-32765 solubility dmso time to enter the dark chamber after receiving foot shock) indicates that memory functions were impaired. Repeated measure ANOVA and post-hoc Turkey's analysis revealed that there were not significant differences between controls and sham groups, thus surgery did not affect preshock latencies (IL) in experimental groups [Figure 1a]. Figure 1 Comparison of latency to enter the dark chamber before receiving foot shock PARP phosphorylation (Initial latency). Each bar represents the mean �� S.E.M. Panel A- There were no significant differences between the control-7, control-21, and sham groups; Panel B- Differences ... Also, there were no significant differences in IL between control-7 and BDL-7 groups. In contrast, There were significant differences between control-21 and BDL-21 groups in IL (P foot shock. So surgery has no effect on the results [Figure 2a]. A memory deficit was observed in BDL-7 (14 days after BDL) and BDL-21 (28 days after BDL) groups in latency to enter dark chamber 7 days after receiving foot shock. There were significant differences between BDL-7 and BDL-21 Thalidomide groups in 7 days after receiving foot shock compared with the corresponding controls groups (P