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This behaviour of ratios might reflect a ��chewing-specific�� motor strategy induced when isometric biting is performed with a ��chewing-like�� gape. If this hypothesis applies, activity ratios should be associated with MIDs of sequent chewing strokes in a similar manner as with incremented jaw gapes in isometric biting. To test this prediction, bilateral surface electromyograms of masseter and anterior temporalis muscles and incisor movements were recorded during unilateral chewing in 52 subjects. W/B-ratios of masseter and temporalis activities and temporalis/masseter-ratios on both sides were calculated. Thymidine kinase The ratios were related to MIDs of consecutive chewing cycles. Three of the four ratios were associated with masticatory MID in the same manner as with jaw gape in isometric biting. In particular with decreasing MID, the masseter W/B-ratio increased from 1��5 to 2��2 (P?Quizartinib mw zirconia materials. Two groups of FDPs with 10 specimens each were machined from white body zirconia blanks (VITA In-Ceram YZ Cubes, KaVo Everest ZS-Blanks) by means of computer-aided design/computer-aided manufacturing systems and subsequently sintered to their final density. The marginal and internal gaps of the frameworks were determined using a replica technique. Afterwards, frameworks were veneered with the recommended ceramics (VITA VM9, GC Initial Zr), and fitting accuracy was evaluated Selleck MK8776 again. Statistical analyses were performed by Student��s t-test with the level of significance chosen at 0��05. With one framework/veneering system (Everest ZS-Blanks/Initial Zr), both marginal gap (P?=?0��019) and internal gap (P?=?0��001) at the premolar retainer were significantly affected by the veneering process. The resulting distortions were directed towards the lumina of the retainers and the mean values of the measured gaps decreased by about 23��8?��m (marginal gap) and 27��3?��m (internal gap). For the other system (In-Ceram YZ Cubes/VM9), no distortions because of the veneering were found. The veneering of zirconia restorations may lead to significant changes in the marginal fit, while the combination of core and veneering material used influences the resulting distortions.