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Overall, gambling behaviors, both normal and problematic, are associated with males, whose rates are much higher than women (e.g., [4, 13, 14]). Some studies have shown that the average age of female problem gamblers is higher than males and that females progress towards gambling disorders faster [15�C17]. This also associates with more severe psychiatric symptoms [18]. In the general population prevalence studies reveal a strong association between problem gambling and specific forms of gambling, for example, lottery, cards and bingo [19], casino table games, and electronic gaming machines [13, 20]. Overall, most people gamble recreationally, considering it a harmless form of entertainment. For some gamblers, however, this behavior becomes problematic and pathological, with this website adverse consequences for the gamblers, their families, and the community, involving impairment or loss of social relationships and financial resources, work and legal difficulties, and even physical health problems and antisocial behavior [21, 22]. It is estimated that, for every individual who develops a gambling problem, from 5 to 10 additional people (i.e., friends, family, and employers) are adversely affected [1]. The individual, MS-275 in vivo social, and economic costs associated with gambling behaviors are so large that gambling and its related problems have become a significant and growing public health issue [3, 17, 23, 24]. This situation requires the development and implementation of both new and alternative approaches to treatment targeting a much broader range of problem gamblers. Unfortunately, only a small proportion of the individuals with gambling disorders (Quinapyramine can handle the problem without external help) [26], but also some external barriers (lack of awareness of services, ignorance of the availability of treatment, geographical distance, existing time commitments, and work and domestic demands) [27]. Helpline services and online counselling (e.g., telephone, e-mail, and chat) could serve as alternative forms of access to treatment for gamblers who reject more traditional options. These interventions are less expensive than formal treatment [2] and can serve wide geographical areas, thus overcoming many barriers, increasing accessibility to professional treatment, and thus attracting new treatment candidates [9, 28]. Some studies have shown several concerns using online treatment support service, namely, guaranteeing privacy and anonymity, emotionally safe environment, convenience and issues regarding time, confidentiality, and flexibility [2, 29, 30].