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Multiple linear regression with log-transformed FGF23 levels as the dependent variable was used to examine the association with potential clinical and biochemical parameters based on clinical judgment. A P UNC2881 Inc., Chicago, IL, USA). Results The mean age was 8.3 �� 4.6 years in the 34 patients (18 males) and 6.5 �� 3.0 years in 45 (24 males) control children. Causes of CKD were kidney dysplasia (n = 11), obstructive or reflux nephropathy (n = 6), nephrotic syndrome (n = 4), glomerulopathies (n = 2), hereditary nephropaties (n = 4), hemolytic uremic syndrome (n = 3), and unknown etiology (n = 4). Vitamin D metabolites, FGF23, and Klotho measurements were obtained at entry (n = 31), and at Months 6 (n = 25) and 12 (n = 15); biochemical, nutritional and dialysis parameters were obtained STI571 monthly. The number of patients decreased during the observation period because of transplantation (n = 11), death due to sepsis (n = 2), and noncompliance (3). Biochemical levels at 6 and 12 months remained similar to baseline values (Table?1). Isolated hypercalcemic episodes resolved promptly by adjusting the dose of calcium carbonate or calcitriol. Serum phosphorus was maintained within age-adjusted ranges with the use of calcium carbonate [32]. Circulating 1,25(OH)2D levels were markedly lower compared with reference control values. Although the levels of 25(OH)D at Months 6 and 12 were not significantly different from baseline, the values tended to diminish throughout the study period, but remained above the cut-off inclusion level of 20 ng/mL (Table?1). Table?1. Biochemical parameters of mineral metabolism in children treated with chronic peritoneal dialysis At entry, FGF23 levels were 215.1 selleckchem �� 303.6 versus 9.4 �� 5.7 pg/mL in the control group (P 20-fold normal controls at all measured time-points (P