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DE at 15?min for the plain drug was found to be 4.02% and 7.52% in 0.1?M HCl and 0.001?M HCl, respectively. From the dissolution data it was observed that more than 90% of the drug was released from both liquisolid and marketed formulation learn more in 30?min in phosphate buffer (pH 6.8) and in 60?min in acetate buffer (pH 4.5, data not shown). So dissolution was carried out at different pH values (1.2, 3.0, 4.5 and 6.8) to differentiate the media and to compare the dissolution profiles. The percentage of drug dissolved at 10 and 30?min (Q10?min and Q30?min) of LSC formulation (F11) was greater than that of marketed product in all dissolution media. The dissolution rate was significantly increased (Pselleck chemical an increase in pH due to the high solubility of the drug at higher pH values. MDT values of the test product were low at all pH, indicating faster dissolution than marketed dosage form. The increased dissolution of the liquisolid formulation is probably due to the drug presenting in a solubilised state in the formulation, which contributes to increased wetting properties, thereby enhancing the dissolution rate. Similarly, the drug will be presented in a state of molecular dispersion as the formulation disintegrates in dissolution media. This will increase the effective surface area of the particles available for dissolution. The liquisolid technique was found to be a promising approach for improving the dissolution of a poorly soluble drug like valsartan. The dissolution of valsartan was significantly increased in liquisolid formulation compared to the marketed product. XRD and IR spectra indicate that there was no change in the crystalline Oxygenase state of the drug and no interactions between the drug and excipients. The increased dissolution rate may be due to increased wetting and increased surface area of the particles. The authors would like to thank Project Director, NIPER - Hyderabad Dr. K. Ravi Kumar IICT, Hyderabad and Dr. VGM Naidu, NIPER-Hyderabad, for providing facilities used in the research. ""The development of controlled release formulations has had a tremendous impact on the drug delivery field particularly for drugs with a narrow absorption window. However, typical controlled release formulations are limited by insufficient retention in the stomach.
