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The rate of thoracoscopic surgery was significantly higher in children (25/33) than in adults. (3/19): P Protease Inhibitor Library mouse re-implantation. Due to the poor result of the re-implantation, a middle lobectomy by thoracotomy was carried out[1] ; Two cases of recurrent pneumothorax and respiratory distress, with one requiring a stay of 4 days in the intensive care unit (ICU); One pulmonary infection required antibiotics; One paralysis of the diaphragm. Rate of surgical complication in the adult was a 30% (6/19), including: A broncho-aspiration endoscopy was required due to Nelson atelectasis; One case of pulmonary infection; One case of pneumothorax; Three cases of hemothorax requiring a second look surgery; The difference in the rate of complications between the children and the adult population was not significant (P = 0.18 Fisher test). The mean duration of hospitalisation was 7.75 days for children versus 7.16 days for adults. There was a non-significant difference in the length of hospitalisation between the two groups (P = 0.75) (Ki2 non-significant difference). The pathological examination concluded that there were 7 sequestrations, 18 CPAM and 8 CPAM associated with sequestrations in the sample of children. In adults, the diagnosis of sequestration was made in 16 cases and CPAM in 3 cases. DISCUSSION The purpose of this study is to suggest Unoprostone the BGJ398 mw best therapeutic strategy for congenital pulmonary malformations in asymptomatic children. In fact, the two populations are different and each one has their own therapeutic indications for surgery. However, there are several arguments in favour of an early treatment of the pulmonary malformation in children: Low complications in children, high rate of symptoms in adults, necessity of an aggressive surgery in adults with increase of complications. Ethically, we cannot propose a prospective study analysing the impact of early thoracoscopic management versus radiological follow up in neonatal population with pulmonary malformation. In our sample, the children are asymptomatic before surgery. They underwent a thoracoscopy, aged mostly between 4 and 6 months, with few complications. This strategy maximises compensatory lung growth[2] and decreases thoracic wall aggression. In our adults group, most patients undergo surgery after presenting with more or less severe complications. A thoracotomy is often required and the rate of post-operative complication is doubled. These data are congruous with literature about the fact that the risk of complication due to congenital pulmonary malformations increases with time.