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Results?The most frequent mutation was in-frame deletions in exon 19 (68.7%). A L858R and G719A were detected in 19 (29.7%) and 1 (1.7%) patient, respectively. Patients with miliary intrapulmonary or disseminated carcinomatosis were more common in female (80.0% vs. 55.1%), non smoker (80.0% vs. 53.1%), and 19 deletion mutation (86.7% vs. 63.3%), however there were no significant difference statistically. They showed relatively shorter PFS to EGFR TKIs (median 9.7 vs, 12.8 months) and poorer overall survival (median 15.9 vs. 29.0 months) compared to patients without miliary metastasis. In multivariate analysis, higher metabolic tumor volume (MTV) in PET-CT was confirmed to be 3-deazaneplanocin A chemical structure an independent predictor of shorter OS, when considered Erastin cell line together with stage, gender and smoking status. Conclusions?The data indicate that NSCLC presenting miliary intrapulmonary or disseminated carcinomatosis were more common in female, adenocarcinoma, non-smoker and 19 deletion mutation was comparatively frequently detected, however there were no statistically significant differences. PFS to EGFR tyrosine kinase inhibitors and overall survival was less in patients with miliary intrapulmonary or disseminated carcinomatosis compared to patients without miliary metastasis. Poor clinical course might be associated with high tumor burden represented by MTV or total lesion glycolysis. AE-RA LEE, JINWOO LEE, CHANG-HOON LEE, SANG-MIN LEE, JAE-JOON YIM, CHUL-GYU YOO, YOUNG WHAN KIM, SUNG KOO HAN, YOUNG SIK PARK Ro3280 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Introduction?The aim of this study was to evaluate the recent epidemiology of lung cancer in a tertiary referral hospital of South Korea. Methods?Consecutive patients, who were newly diagnosed as lung cancer from June 2011 to December 2012 in Seoul National University hospital, were included in this retrospective study. The clinical and pathologic characteristics were reviewed. Results?All 979 of newly diagnosed lung cancer patients were included. The mean age at diagnosis was 65.6?��?10.2 years old and 652 (66.6%) were males. Among 979 patients, 349 (35.6%) were never-smokers. In non-small cell lung cancer group (n?=?887), stage IV was the most common (326, 36.8%). Adenocarcinoma was the major pathologic diagnosis (555, 56.7%). Compared to the data of previous national surveys, the proportion of adenocarcinoma was increasing from 30% in 1997 and 36.1% in 2005. The clinical characteristic of the patients with adenocarcinoma showed younger age (63.7 vs. 68.1, P?