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14 Furthermore, CAD/CAM technique is ideal for fabrication of oral and facial prostheses.15 It is a feasible solution in limited cognitive skills patient.7 BLZ945 solubility dmso CAD/CAM-generated all-ceramic restorations facilitate the rebuilding of deeply destructed teeth regardless of the location of the cavity margins.6 The aim of the study The main objective of this paper was to review the chair-side CAD/CAM clinical performance. The author��s reviewed all valid research material related chair-side CAD/CAM from a database of articles available from 2004 up to 2014. Data sources included PubMed, Medline, Embase, Science Direct and Wiley Online Library. Only relevant INSRR literature was considered. This paper gives an in depth insight on chair-side CAD/CAM clinical performance. It gives clinicians a detailed understanding of the advantages, drawbacks, indications, contraindications of chair-side CAD/CAM. Clinicians are able to correlate this knowledge during case selection and placement for better longevity and performance of restorations. Discussion Material comparison Numerous studies compared the materials used in chair-side CAD/CAM system (Table 1). Magne et al. (2010) studied fatigue resistance of CAD/CAM composite resin and ceramic posterior occlusal veneers found that composite resin (Paradigm MZ100) had significantly higher fatigue resistance BMS754807 (P occlusal veneers (P