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Procedure: The exercise program was performed three sessions per week for 24 weeks. The exercise program included 40 minutes, including 5-10 minutes for warm-up, 25 - 30 minutes of exercise (walking), and 5 minutes for cooling down) MET (Metabolic Equivalent) value Staurosporine solubility dmso of various common activities was light intensity activity: Resminostat patient health based on Rhoten Fatigue Scale (RFS). To assess the reproducibility of gas exchange parameters, the cardiopulmonary test was repeated 3 to 5 days before starting the protocol for all patients and considered as baseline. The examination was repeated at the end of the study. Patients in the control group received educational support but no exercise protocol; they were asked to continue their individually prescribed cardiovascular medications and their usual lifestyle but not to do any physical activity that caused breathlessness or fatigue and were supervised by their nurse and physicians. Blood pressure and heart rate were measured before and after exercise. Drug treatment was not changed during the study in control and experimental groups. To further minimize the bias, we did not let the cardiologist who was informed of echocardiography results whether the participant was control or case (The physician who did perform echocardiography and the nurse who did data gathering were different from the physician and nurse that were monitoring the exercise). 3.4. Instruments The required data were collected by MacNew Heart Disease Health-Related Quality of Life questionnaire (physical Dorsomorphin supplier performance, limited activity following mental problems, limited activity following physical problems, energy and fatigue, physical problems, mental health, social performance and body pain). The self-administered MacNew questionnaire is designed to evaluate how daily activities and physical, emotional, and social functioning are influenced by heart disease, demographic characteristics, and echocardiography (2). Each of these 8 dimensions may be scored from 0 to 100. Scoring is performed according to criteria of SF-36 standards, with higher scores indicating better function (24, 25).