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Both TNBS and DSS caused a localized action on periodontal tissues, with alveolar bone loss observed in both maxilla and mandibles, with progression Small Molecule Compound Library in a time-dependent manner. Bone loss was detected as early as week?7, with more severe periodontitis increasing over the 18?weeks (p?Unoprostone with periodontitis. BGJ398 PAD-2 and PAD-4 (protein and mRNA) as well as citrullinated proteins are present in inflamed gingiva, and anti-CCP antibodies can be detected in the GCF of some patients. Tissue expression of citrullinated proteins and PAD increased with the severity of inflammation. The presence of anti-CCP antibodies in GCF was almost exclusive to a subset of patients with periodontitis. Increased expression of these proteins in inflamed gingiva lends support to the notion that periodontal inflammation contributes to the inflammatory burden in a similar way to rheumatoid arthritis. ""Meulman T, Peruzzo DC, Stipp RN, Gon?alves PF, Sallum EA, Casati MZ, Goncalves RB, Nociti FH Jr. Impact of Porphyromonas gingivalis inoculation on ligature-induced alveolar bone loss. A pilot study in rats. J Periodont Res 2011; 46: 629�C636.?2011 John Wiley & Sons A/S Background and Objective:? Periodontitis is a polymicrobial infection characterized by the loss of connective tissue attachment, periodontal ligament and alveolar bone. The aim of this study was to evaluate the impact of Porphyromonas gingivalis inoculation on the ligature-induced alveolar bone loss (ABL) model in rats. Material and Methods:? Forty male Wistar rats were randomly assigned to the following groups: G1, control (n?=?10); G2, ligature-induced ABL (n?=?15); and G3, ligature-induced ABL?+?P.