Ones Selling Point Of PRDX4

When bound to the hydroxyl group, the average d(C��O(H)?Ow) distance is 2.59?��?0.06?? (Fig. 11 ? a); when bound to a carboxyl(ate) carbonyl group, the average d(C=O?Ow) distance (2.77?��?0.07??) becomes close to water hydrogen-bond distances (Figs. 11 ? b and c). The shortest reported hydrogen-bond lengths are close to 2.4??. Such a short length is found in the CACTUW structure (Vishweshwar et al., 2004 ?), where the (C=O)O��H?Ow distance is close to 2.48?? and involves an anti conformer (Fig. 9 ? a). Interestingly, only 44 water molecules establish a hydrogen bond with the lone pair of the carboxyl��OH group either in syn or anti (compared with the ??2800 water molecules found around the other groups), confirming its poor acceptor potential. The associated distances are close to 2.80??. Figure 11 Histograms showing the distance distribution between the two O atoms directly involved in the carboxyl(ate)�Cwater Bleomycin hydrogen bond. For clarity, only water molecules positioned in a 1?? slice above and below the plane defined by the ... 3.2.6. Catemers ? Nomenclature: The dimer nomenclature can be adapted without major modifications to the catemer motifs for which two classes can be defined: (i) the homo-catemers involving the formation of a continuous chain of the same dimer and (ii) the hetero-catemers involving two alternating dimer types. In the latter case, we impose this website the convention that the syn conformer precedes the anti conformer. Thus, the SS-A��AS-S code should be used instead of the AS-S��SS-A code. In the current CSD release, four homo- and four hetero-catemer types were identified (Table 4 ? and Fig. 12 ?). Figure 12 Examples of the eight catemer types identified in the CSD. The C and O atoms not belonging to the interacting carboxyl groups are shown in PRDX4 light blue. The white and red dots mark the position of the connected carboxylic groups in the catemeric chain. ... Table 4 Number of catemer-containing structures in the CSD Catemer formation rule: The SS-S and SA-S homo-catemers are the most represented followed by the SS-A��AA-S hetero-catemers. Three other catemers are poorly represented but still present in the CSD. These catemers involve the eight ��carbonyl dimers�� shown Fig. 4 ?. After closer examination of the catemer nomenclature (Table 4 ?), a simple rule emerged. If the dimer starts with a syn or an anti conformer it should end with an identical conformer. Thus, the SS-S, SA-S, AS-A and AA-A dimers form homo-catemers since the first and the last conformers are identical, while the SS-A, SA-A, AS-S and AA-S dimers need to associate with a complementary motif and can only form hetero-catemers. According to this rule, all eight possible homo- and hetero-catemer combinations were identified in the CSD, although the SS-A��AS-S (ROZHEU; Dawid et al., 2009 ?) and SA-A��AS-S catemers (MEKLOE; Das & Desiraju, 2006 ?) were identified in only one instance.