Our Advanced GSK2118436 Concept Performs While You Fall Asleep!
50�C24 Hz range) and each electrode. For a given episode, we defined an epoch longer than a duration threshold, DT (set to three cycles in our analysis) during which wavelet power at each frequency exceeded a power threshold (PT). This PT was chosen as follows in the 5 min segments: (1) The EEG was wavelet transformed (Morlet wavelet, window of six cycles) at 47 logarithmically spaced frequencies in the range 0.50�C25 Hz. The average of the log-transform of these wavelet values yielded the wavelet power spectrum. (2) The background noise spectrum assumed the form Power(f) = Af�Ca. The estimate of this background has been obtained by fitting the observed spectrum (at each electrode) with a linear regression in log�Clog units. The background at f? Megestrol Acetate has been estimated on the mean of its corresponding ��2(2) probability distribution function. The PT was set to the 95th percentile of the theoretical probability distribution. The proportion of time in which PD-0332991 in vivo significant oscillations were detected within a 5 min sleep period was termed Pepisode (Caplan et al., 2001, 2003; Caplan and Glaholt, 2007; van Vugt et al., 2007). The BOSC analysis was performed on the EEG signals recorded from each scalp location during the last 5-min of REM sleep before awakening and was averaged across subjects. Then, Pepisode values in correspondence of the theta peak frequency were compared between REC and NREC conditions by paired t-tests. Bonferroni correction (Sankoh et al., 1997; Perneger, 1998) was applied (r = 0.69; 28 tests) and �� level was adjusted to 0.018 (t ��3.46). Results EEG Power Spectra The statistical maps (Figure ?Figure11) show a predominance of theta activity over the right-frontal regions (Fc2) in the REC compared to NREC condition (t = 2.47, p = 0.065). Furthermore, maps show a lower theta power in centro-occipital regions (Oz, t = �C2.69, p = 0.043; O2, t = �C2.82, p = 0.037) and a lower temporal sigma activity in REC vs. NREC condition (T8, t = �C2.64, p = 0.046). However, these comparisons are not statistically significant after the Bonferroni correction. FIGURE 1 Statistical maps http://www.selleckchem.com/products/dabrafenib-gsk2118436.html reporting topographic EEG power differences, assessed by paired t-tests, between the REC and NREC conditions. Values are expressed in terms of t-values: positive t values (warmer colors) indicate a prevalence of the REC over the NREC ... Detection of Oscillatory Activity As depicted by Figure ?Figure2A2A, which details EEG oscillations averaged across all the derivations, the EEG recordings of the pre-awakening segment shows three peaks: alpha band peaking at 9.85 Hz, theta band peaking at 6.06 Hz and delta band peaking at 2.83 Hz. FIGURE 2 (A) Mean proportion of time [Pepisode (f)] of EEG activity during last segment (5 min) of REM sleep during which oscillations were detected by the BOSC method at each frequency in the 0.25�C25.00 Hz Individual oscillations detected across all frequencies ...
