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The data from treatment cycles were included until IVF began. The demographics of the two groups were analyzed by summary statistics and by univariate analysis. Survival analysis using Kaplan-Meier plots was used to display cumulative pregnancy rates for both groups and to determine the mean time to pregnancy. Number needed to treat (NNT) was calculated by the number of treatment cycles needed to achieve one pregnancy. For each outcome, a p value less than 0.05 (two-tailed) was used to determine significance. The subjects were further dichotomized into age groups, either ��35 or >35; then the demographics and outcomes were compared for these age groups. 3. Results 3.1. Baseline Characteristics The demographic features of the MLF and control cohorts are shown in Table 1. The two groups were similar in terms of age, BMI, smoking history, partner's smoking history, and length of relationship. PD173074 solubility dmso There was a statistically significant difference in the ethnic distribution between the two groups, with a higher percentage of the MLF group reporting ethnicity as white (80.8% versus 60.2%, MLF versus control) and a lower percentage as black (6.4% versus 27.9%, p MRIP control group (24.9 versus 28.5, p Temsirolimus chemical structure differences in gravidity, day 3 FSH level, day 3 estradiol level, prior use of oral contraceptive pills, intraoperative chromopertubation findings, and semen analysis results. For individual cycles that led to pregnancy and those that did not, the endometrial thickness (9.7 �� 2.6?mm versus 8.8 �� 2.6?mm, p = 0.07) and the number of dominant follicles (1.6 �� 1.2 versus 1.6 �� 1.0, p = 0.95) were comparable. Univariate analysis examined the effect of each of the variables on the reproductive outcomes, namely, age, BMI, race, smoking history, FSH level, estradiol level, HSG findings, intraoperative chromopertubation findings, and semen analysis. None of these variables were found to have a significant impact on the outcome (data not shown). Operative times were similar for the two groups (60.1 �� 17.7 minutes versus 62.6 �� 36.2 minutes, p = 0.59, MLF versus control). Minimal surgical complications were noted for each group (0% versus 3.5%, p = 0.29, MLF versus control). 3.2. Reproductive Outcomes The Kaplan-Meier analysis of the cumulative pregnancy rate is shown in Figure 2. Overall, the pregnancy rate for the MLF group was 40.0%, compared to 28.7% for that of the control group (p = 0.13). The average time to pregnancy for the MLF group was 13.4 weeks compared to 18.
