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Patients older than 20 years old who were planned for elective CABG with Laryngeal view grade from 1 to 3, according to the American Society of Anesthesiologists (ASA) guideline on management of the difficult airway (16), were included in this study. The anesthesia and surgical techniques were the same for all the patients. Patients with liver or renal dysfunction, metabolic disorders, and left bundle branch block (LBBB) were excluded from study. In addition, patients with indications of emergency surgical operation, those using opioids, patients with a history of drug sensitivity or seizures, smokers, and those with Liraglutide mw ejection fraction (EF) Oxymatrine in compliance with Helsinki declaration on ethical principles for medical research involving human subjects (17). 3.2. Treatment Plan and Outcome Measures Patients in pregabalin and control groups respectively received single dose of 150-mg pregabalin capsules (LYRICA, Pfizer Inc, Germany) and placebo two hours before surgery. Severity of pain after 4, 12 and 24 hours were measured in patients by a visual analog scale (VAS) and recorded (18). Patients having VAS scores > 3 received 0.1 mg/kg of intravenous morphine up to 8 mg. Background data including arterial blood pressure, heart rate, respiratory rate, and time of extubation were recorded. 3.3. Statistical Analysis Numerical data were expressed as mean �� standard deviation (SD). As the data showed normal distribution pattern by Kolmogorov-Smirnov test as well as homogeneity of variance, group comparisons were made by Student��s t test. Chi square test was used to examine differences between qualitative data. In all comparisons, statistical significance levels were considered at P Verubecestat order Rate of females in pregabalin and control groups were similar and identical to its frequency in total patients. Mean age of control and pregabalin groups were 57.9 �� 8.6 and 54.7 �� 8.3 years, respectively (P > 0.05). Although our exclusion criteria was the patients age > 20 years, the age of patients ranged from 35 to 70 years due to occurrence of the coronary artery events at older ages. According to our results, no hemodynamic changes were observed between two groups (P > 0.05) (Table 1). Comparison of severity of pain showed significant differences between two groups at 4, 12, and 24 hours of surgery (Figure 1) (P