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Of 65 patients chronically infected with S.?aureus, 37 received 139 courses of IV antimicrobial agents with activity against S.?aureus (mean duration, 15?days; range, 6�C31?days). Administration of IV antibiotics increased the time to the next sample with growth of S.?aureus: the mean interval between two positive samples was 68?days if IV treatment had been administered, in contrast to 49?days if no IV treatment had been administered (p?0.003). When S.?aureus recurred in sputum after IV treatment, the isolate belonged to a different clone in 33 of 114 (29%) intervals, in comparison http://www.selleckchem.com/products/LY294002.html with 68 of 232 (29%) intervals where IV treatment had not been prescribed (OR?0.98, 95%?CI?0.60�C1.61). In conclusion, we show that 2?weeks of IV antimicrobial treatment can significantly suppress chronic staphylococcal infection in CF, but is not associated with the eradication of persistent bacterial clones. ""Clin Microbiol Infect 2011; 17: 830�C835 Healthcare workers�� mobile phones provide a reservoir of bacteria known to cause nosocomial infections. UK National Health Service restrictions on the S6 Kinase utilization of mobile phones within hospitals have been relaxed; however, utilization of these devices by inpatients and the risk of cross-contamination are currently unknown. Here, we examine demographics and characteristics of mobile phone utilization by inpatients and phone surface microbial contamination. One hundred and two out of 145 (70.3%) inpatients who completed a questionnaire detailing their opinions and utilization of mobile phones, also provided their mobile phones for bacteriological analysis and comparative bacteriological swabs from their nasal cavities; 92.4% of patients support utilization of mobile phones by inpatients; indeed, 24.5% of patients stated that mobile phones were vital to their inpatient stay. Patients in younger age categories were more likely to possess a mobile phone both inside and outside hospital (p?HER2 inhibitor setting is popular and common; however, we recommend that patients are educated by clear guidelines and advice on inpatient mobile phone etiquette, power charging safety, regular cleaning of phones and hand hygiene, and advised not to share phones or related equipment with other inpatients in order to prevent transmission of bacteria. A number of studies have consistently reported that 5�C21% of healthcare workers�� mobile phones provide a reservoir of bacteria known to cause nosocomial infections [1�C7].
