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Additionally, the intratumoral lymphocyte and immature dendritic cell infiltrate is reduced or absent in PDTC and ATC [16]. NLR is cheaper than serum CRP, which is now routinely measured as part of the cancer work-up, easily calculated, and universally available. We hypothesized that CYTH4 the NLR could be used as an effective discriminating tool in these subtypes of thyroid cancer. METHODS Patients who underwent thyroid surgery in Gwangju and Hwasun Chonnam National University Hospitals between January 2004 and March 2009 were identified from a prospectively maintained database. The database is prospectively maintained and all patients are followed-up regularly by a team of thyroid cancer specialists. In total, 3,870 patients were enrolled, including some patients who did not undergo any surgical procedures but had a definite diagnosis on cytological examination. The NLR was defined as the absolute neutrophil count divided selleckchem by the absolute lymphocyte count. For patients who underwent surgery, the NLR was calculated from the full blood count routinely performed on the 7th-14th day before surgery. For patients who did not undergo surgery, the NLR was calculated from the full blood count performed as part of the diagnostic process. The median NLR of all 3,870 patients was 1.57, and evenly divided into 1,935 patients on each groups: the neutrophilic high NLR group and the lymphophilic low NLR group. The preoperative and postoperative profiles were analyzed. Patients were excluded from the study for the following reasons: not enough data on follow-up, pediatric patients, patients with other cancer history or distant metastasis, and previous history of infectious conditions such as pulmonary or visceral tuberculosis. Data were summarized with the number of subjects and the mean �� standard deviation or median (range) value. We used the t-test to compare continuous variables between each group and the chi-square test for categorical variables. Mann-Whitney U test was used to compare categorical end points and the two-sample t-test was used to compare continuous variables. A receiver operating characteristics curve was constructed to estimate the optimal cutoff value of pretreatment NLR and other variables. Subsequently, the variables with P Selleckchem MK1775