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The study included 38 patients coinfected with HIV and CHC who were injecting drug users. To draw a comparison of immunological indices, 36 patients with HIV/CHC but not injecting drug users were concurrently examined. In patients who used injecting drugs, only an intravenous injection of drugs was marked; however, the abuse drug by the intranasal route was not defined. The abuse drug by the intranasal route was not marked in patients who were not injecting drug users. The patients�� description is presented in Table 1. In general, the study groups were comparable (P>0.05). Table 1 Characteristics of coinfected HIV/CHC patients The average age of injecting drug users with HIV/CHC was 31.1��0.6 years (median 30.0 years) while the average age of patients with HIV/CHC but not PFKM injecting drug users constituted 33.4��0.7 years (median 33.5 years). Sex composition of the group featuring injecting drug users with HIV/CHC consisted of 32 males (84.2%) and six females (15.8%). The sex distribution of the group of patients with HIV/CHC but not injecting drug users had a ratio BLZ945 mouse of 29 (80.6%) versus seven (19.4%), respectively. Our study was conducted prior to the therapy. Moreover, the patients essentially were in stage I and II of HIV infection without clinical CHC, and they had early stages of fibrosis. It should be noted that patients coinfected with HIV/CHC require individual approach that will take into account their state of immunodeficiency. Patients were followed up in view of their further BMS-754807 purchase treatment. Highly active antiretroviral therapy (HAART) was prescribed for HIV/CHC coinfected patients with number of CD4-lymphocytes