Reviewed - The (-)-p-Bromotetramisole Oxalate Benefits As well as , Negatives

Footnotes There are no financial or other issues that might lead to conflict of interest.""Hen's egg white (EW) and cow's milk (CM) are the most learn more common causes of food allergy (FA) in infants and young children.1 The estimated prevalence of egg and CM allergies ranges between 0.5 and 2.5%.2,3,4,5 Although the diagnosis of immediate-type egg and CM allergies is often based on a detailed clinical history, physical examination, and the detection of specific IgE (sIgE) to food allergens,6,7 oral food challenges (OFCs) are still considered the gold standard test for diagnosis. However, such tests are time-consuming and associated with a risk of potentially severe clinical symptoms, including anaphylaxis.3,8,9 Nevertheless, there are many cases where the use of OFC is unavoidable, (-)-p-Bromotetramisole Oxalate because the ingestion of the suspected food often produces an unclear reaction and clinical symptoms can be vague. In addition, clinicians occasionally encounter children who have positive sIgE against a food that has never been eaten. It would be more desirable to have access to a good alternative diagnostic method to OFC. To avoid unnecessary OFC for the diagnosis of food allergies, the use of a predictive diagnostic decision point (DDP) of sIgE levels has been proposed and is currently in wide use in clinical settings.10,11,12 The quantification of sIgE antibodies in serum was reported in some studies on an association with positive challenge tests and clinical symptoms, while others found no correlation between the sIgE levels and clinical reactivity.11,13,14,15 Moreover, the DDP value of sIgE varies according to country and race.16,17 For example, a recent study demonstrated that the sensitivity and specificity of the predictive DDP for EW-sIgE were low in Korean children,17 while a Japanese study presented much higher levels of sIgE for the diagnosis of egg or CM allergy than the previous JNJ-26481585 mouse reports.16 Further studies to evaluate the utility of sIgE levels in the diagnosis of egg and CM allergies are needed, because there may be ethnic differences between Japanese and Korean people. Moreover, the sample size of the previous Korean study was small, the age of the study population was limited to