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05. Statistical analyses were performed using SPSS version 15.0 statistical software (SPSS, Inc., Chicago, IL). Eligible subjects were assigned to two study groups in a 1:1 ratio by permuted block randomization code, using a 2?��?2 blocking size design. Sample size was determined by power of the test set 0.9, value for �� 0.05, and effect size difference was 0.8. Estimated total sample size was 68 patients which calculated by G power 3.15. With about an estimated 20% drop out rate in this study, a total of 82 patients were recruited to this study. After the first treatment, 10 dropped out Thalidomide after the first treatment, and 72 patients completed the trial and were evaluable in this study, including 29 women and 43 men. Their mean age was 41.5 years (range, 22�C74 years) and the mean injury duration was 8.7?��?8.1 years. Of these patients, 31 had cervical SCIs, 39 had thoracic SCIs, and two had lumbar SCIs. Fifty-six patients (77.8%) experienced complete injury, while the other 16 patients (22.2%) had incomplete injury. The injury and the American Spinal Injury Association (ASIA) classifications are listed in Table I. Among the overall patients, 47 (65.3%) used periodic or intermittent CIC to empty their bladders. At the end-point, 38 patients were randomized to receive 200-U of onabotulinumtoxinA and 34 patients were assigned to Ribociclib molecular weight receive 300-U of onabotulinumtoxinA injected into the detrusor muscle. All of these patients completed the injection and visitation protocols. The distribution of injury severity and injury level were similar between the two groups. The median injury duration was 8.5 years in the 200-U dosage group and 8.0 years in the 300-U dosage group (P?=?0.282). Table II shows the changes in urodynamic parameters after repeated onabotulinumtoxinA injections. Significant increases of CBC and PVR and a significant decrease of Pdet.Qmax were noted after onabotulinumtoxinA injections in both groups. There were no significant differences in the changes in CBC, PVR, and Pdet.Qmax between the groups at the end of the study. Figure 1 shows the therapeutic results of onabotulinumtoxinA on incontinence and QoL measures including the UDI-6, IIQ-7, and QoL-I scores between baseline and end-point by dosage group. A significant improvement in these measures was noted after repeated onabotulinumtoxinA injections in both dosage groups, and there was no significant difference in the changes between PD-1/PD-L1 inhibitor 2 the two groups. The UDI-6 score decreased from 11.4?��?3.6 to 7.61?��?3.75 and 10.4?��?4.13 to 7.43?��?2.24 in the 200-U and 300-U groups, respectively (all P?
