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To study the effect of both factors in in vivo 1H NMR spectra acquired at ultrahigh field, a reference spectrum was generated by summing nine in vivo 1H NMR spectra obtained in rat brain with a STEAM sequence at 16.4?T. By progressive deterioration of linewidth and SNR, 6400 single spectra were generated. In an accuracy study, the variation in the mean concentrations of five metabolites was mainly dependent on SNR, whereas 11 metabolites were predominantly susceptible to the linewidth. However, the standard deviations of the concentrations obtained were dependent almost exclusively on the SNR. An insignificant correlation DNA Damage inhibitor was found between most of the heavily overlapping metabolite peaks, indicating independent and reliable quantification. Two different approaches for the consideration Obeticholic Acid of macromolecular signals were evaluated. The use of prior knowledge derived by parameterization of a metabolite-nulled spectrum demonstrated improved fitting quality, with reduced Cram��r�CRao lower bounds, compared to the calculation of a regularized spline baseline. Copyright ? 2012 John Wiley & Sons, Ltd. ""There has been growing interest in understanding energy metabolism in human embryos generated using assisted reproductive techniques (ART) for improving the overall success rate of the method. Using NMR spectroscopy as a noninvasive tool, we studied human embryo metabolism to identify specific biomarkers to assess the quality of embryos for their implantation FARP1 potential. The study was based on estimation of pyruvate, lactate and alanine levels in the growth medium, ISM1, used in the culture of embryos. An NMR study involving 127 embryos from 48 couples revealed that embryos transferred on Day 3 (after 72?h in vitro culture) with successful implantation (pregnancy) exhibited significantly (p?