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[6] The mean distances between skin and superficial lying part of the brachial plexus were found to be 16.5 �� 0.7 mm in male and 14.5 �� 0.5 mm in female volunteers, which are longer than the SD we have observed in our study. This dissimilarity might be due to the difference in the surface landmark, the ethnicity of the study population and the demographic profile between the two studies. In a study on 15 healthy volunteers, the high-resolution ultrasound probe was used to scan the supraclavicular region in coronal oblique plane.[7] The mean skin-to-nerve distance was found to be 0.9 �� 0.3 cm. In another study on 20 healthy volunteers, sonographic assessment revealed that the brachial plexus is relatively superficial in supraclavicular region with a depth of 1�C2 cm.[8] However, the distance between the skin and the superficial and deep neural element SB203580 research buy was not measured separately. Moreover, all these studies were done in Western population and the findings may not be applicable to the Indian population. The deposition of drug at the corner pocket is practised by some sonography users for ultrasound-guided supraclavicular brachial plexus block.[9] Significant correlations have Fulvestrant purchase been observed between weight, BMI and the depth of corner pocket in a study on Indian population.[4] We also found significant correlation between the weight, BMI and SD and LD between skin and the neural element. Supraclavicular brachial plexus block is effective but may sometimes be complicated by pneumothorax because of needle advancement beyond the plexus and injury to pleura. Pre-procedural scan and measurement of the depth would be beneficial for selection of the needle size as well as advancement of needle during ultrasound-guided brachial plexus block. We suggest that use of needle with 3 cm shaft would be sufficient to reach the sheath of the brachial plexus and proximal to the neural elements during performance of the block in patients with weight and BMI ranging from 55 to 79 kg and 17.75 to 28.54 kg/m2, respectively. Our study population did not have older (>50 years) or obese (BMI > 30 kg/m2) patients. We studied the variation in depth on 87 patients only. A study on larger number is needed to derive a formula that can predict the depth of neural element based on weight and/or BMI. Additionally, Alizarin measurement of neck circumference would probably be helpful in predicting the depth of brachial plexus and needle size to be used. CONCLUSION The difference between the most superficial and deep neural elements of brachial plexus was