S1PR1 Suggestions In Addition To The Misconceptions

The kinetic models employed in the present study were zero-order, first-order, Higuchi, and Hixson-Crowell models. The data from the dissolution studies conducted were fitted into the individual kinetic S1PR1 models to determine their linearity using the coefficient of regressions. In all the film formulations the highest R2 values were recorded for the Higuchi model which describes drug release by Fickian diffusion. The Higuchi model is mostly applied to describe drug dissolution from various modified release pharmaceutical dosage forms especially in transdermal systems and matrix tablets with water soluble drugs [42]. Table 8 Drug release kinetic models of diclofenac sodium ODF formulations. 4. Conclusion In can be concluded from the study that Albizia and Khaya gums possess the requisite physicochemical properties for use as film formers for the development of oral dissolvable films. Diclofenac sodium ODFs were successfully formulated using the gums through the solvent Bleomycin chemical structure casting technique. The ODFs produced generally exhibited satisfactory physicomechanical properties with most of the formulations attaining over 75% drug release in phosphate buffer pH 6.8 within 7?min. The study has demonstrated the potential of Albizia and Khaya gums as vehicles for the fabrication of diclofenac sodium ODFs and with film properties enhanced through addition of HPMC in the formulation. Acknowledgments The authors gratefully acknowledge the technical assistance of the technicians in the Departments of Pharmaceutics and Pharmaceutical Chemistry, KNUST, Kumasi, Ghana. Competing Interests The authors declare that there is no conflict of interests regarding the publication of this paper.""Eye is the most simply accessible site for topical administration of a medication. Drugs are commonly applied to the ocular system for a localized action on the surface or in the interior of the eye [1]. The major challenge to the formulator is to outwit these barriers without causing any tissue damage [2]. The cornea is Rigosertib mouse the anterior layer of the eye, comprised of epithelium, stroma, and endothelium. However, this layer represents a mechanical barrier restraining the delivery of drug molecules. Due to their high lipid content, the epithelium and the endothelium are considered as an obstruction to the passage of hydrophilic molecules. The stroma is characterized by a high water content that makes this layer impermeable to lipophilic molecules [3]. Corneal barrier also plays a considerable role in low ocular bioavailability due to which only