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Mean thickness for each cortical ROI was calculated by averaging the mean cortical thickness measurements at each vertex within a given ROI. Normalized amygdala and hippocampal values were calculated as follows: [raw data volume/ICV]*1000. For each of these ROIs the right- and left-hemisphere measurements were pooled together. Figure 1 Cortical parcellation units (PUs) involved with a priori hypothesis as obtained by Freesurfer's segmentation. The orbitofrontal cortex was composed by the medial and lateral part, while the anterior cingulate cortex included the subregions rostral- and ... Voxel-based morphometry To corroborate Freesurfer-related findings we further performed a voxel-based analysis investigating GM volume changes. Data were processed using selleck chemical the SPM8 software (http://www.fil.ion.ucl.ac.uk/spm), where we applied VBM implemented in the VBM8 toolbox (http://dbm.neuro.uni-jena.de/vbm.html) and incorporated the DARTEL toolbox that was used to obtain a high-dimensional normalization protocol. Images were bias-corrected, tissue classified, and registered using linear (12-parameter affine) and nonlinear transformations, within a unified model. Subsequently, the warped GM segments were affine transformed into MNI space and were scaled by the Jacobian determinants of the deformations (modulation). Finally, the modulated volumes were smoothed with a Gaussian kernel of 10-mm full width at half maximum (FWHM). Statistical analysis The difference in sex distribution was evaluated with chi-square test. The differences between demographical OPHN1 data were assessed A-1210477 clinical trial using unpaired t-test. Correlation analysis was performed using r's Spearman. All statistical analyses had a two-tailed alpha level of