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There were 40 ��true positive�� lesions detected on SD CT, including liver cysts (n = 9), kidney cysts (n = 7), gall stones (n = 2), diverticulosis (n = 3), fatty liver (n = 2), fluid collections (n = 3), pancreatic lesions (n = 2), hernias (n = 2), splenomegaly (n = 1), and other lesions (n = 9) including lymph nodes, diverticulitis, liver lesion, adrenal nodule, and urinary bladder diverticulum. Nine lesions were missed on RD CT regardless of IRTs including liver cysts (n = 3, 3-5 mm), gall stone (n = 2, RO4929097 supplier four pseudo lesions including two liver lesions (3-4 mm), kidney cyst (INPP5D C-2, and C-3). The gall bladder stone (arrows) ... Table 5 Subjective image quality scores for reduced dose C-1, reduced dose C-2, and reduced dose C-3 Lesion conspicuity was acceptable in 4/20 lesions with RD C-1, 6/20 lesions with RD C-2, and 10/20 lesions with RD C-3. Lesion margin was better seen on 7/22 patients with RD C-1, 10/22 patients with RD C-2, and 13/22 patients with RD C-3 (P = 0.8). Liver and kidney parenchyma were not sufficiently seen in most patients with RD IRTs (Figure ?(Figure3).3). Also visibility of other abdominal structures (adrenals, gall bladder, bowels, peritoneum, and urinary bladder) was not sufficient for diagnostic confidence at RD CT regardless of IRTs. Patients with a greater body size (> 30 kg/m2) associated Nutlin-3 order with more image noise and artifacts that can affect the diagnostic confidence. Interobserver agreement for subjective image quality among was moderate (k = 0.41-0.55). Objective image quality Mean HU values and objective image noise are summarized in Table ?Table6.6. There was no significant difference in CT numbers across respective IRTs (P = 0.9) of all vendors. Mean objective image noise in liver was significantly lower for RD A-1 compared to both RD A-2 and RD A-3 images (P