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In this FKBPL study, we discovered allele 2 for DXS548 and allele 1, 2, 5, and 6 for FRAXAC1, which have not been found in previous reports on mainland Chinese and Taiwanese populations (Table?(Table1).1). The most abundant alleles for FRAXAC2 were alleles 7+, 4, and 6 in the Chinese population (Fig.?(Fig.1C).1C). In general, the Chinese population has a smaller number of alleles and a lower EH than Caucasians and African Americans (Table?(Table2).2). With respect to DXS548, the most dominant allele (allele 7) was the same among the three populations (Fig.?(Fig.1A).1A). The most common alleles for FRAXAC1 and FRAXAC2 in the Chinese population differ from that in both Caucasians and African Americans (Fig.?(Fig.1B1B and C). The allele distributions for all three STR markers were significantly different between the Chinese population and Olaparib the other two populations (Fig.?(Fig.11A�CC). Table 1 Allele distributions for DXS548, FRAXAC1, and FRAXAC2 in unaffected and fragile X Chinese populations Figure 1 Frequency distribution of STR markers flanking the FMR1 gene. DXS548 (A), FRAXAC1 (B), and FRAXAC2 (C) allele distributions among the unaffected Chinese (n?=?566; gray bars), Caucasians (n?=?721; white bars), and African ... Table 2 Diversity of FRAXA and flanking STRs in unaffected Chinese population compared with other groups Our analysis identified 33 distinct haplotypes (DXS548-FRAXAC1-FRAXAC2) in the Chinese population, and the most frequent haplotypes were 7-4-7+ (0.440), 7-3-4 (0.173), and 7-4-6 (0.141). The CGG repeat lengths and patterns in unaffected Chinese population Collectively, we analyzed 1113 unaffected Chinese individuals (534 males and 579 females) for CGG repeat lengths, and the CGG repeat patterns of 534 males were further determined by sequence analysis (32 males were excluded from the analysis of FMR1 CGG repeat due to lack of DNA sample). We identified Trametinib nmr 33 different CGG repeat lengths on 1692 Chinese chromosomes (Table?(Table2).2). Chinese population has a similar number of CGG repeat lengths when compared with that of Indonesian and Japanese (Table?(Table2).2). The most frequent allele was (CGG)29 followed by (CGG)30 in the Chinese population (Fig.?(Fig.2A).2A). Chinese population show both a smaller number of CGG repeat lengths and lower EH than Caucasians and African Americans (Table?(Table2).2). The distributions of the CGG repeat lengths were statistically different between the Chinese population and the other two populations (Chinese vs. Caucasians: ��2?=?230.2, P?
