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A collagen membrane (Bio-Gides, Geistlich Pharma AG) was used to cover the sinus window of both grafted sites. After a healing period of 6?months and CT-scan analysis, the implant placement procedure was performed and bone biopsies were taken with a trephine bur from lateral window and processed for histological and histomorphometric analyses (ImageJ software). Results After 6?months of healing, in all regenerated sites implants could be placed with primary stability. No differences in the clinical features of the test and control site were reported in all patients. Results of histological analyses revealed the presence in both groups of the grafting material that resulted integrated in the surrounding bone. No signs of inflammatory reaction were reported. Histomorphometric analyses revealed at approximately 6?months post sinus floor evaluation Adenylyl cyclase surgery that the percentage of BioOss present in the biopsies taken from the test site was slightly lower compared to control sites, while the percentage occupied by marrow spaces was comparable between the test and the control specimens (P?selleck screening library of the biomaterial appear to be influenced by cells as well as the state of bone tissue maturation. Both human bone marrow aspirate concentrate and PRP may provide therapeutic benefits in bone tissue engineering applications. ""B. Demiralp1, E. Dogan1, F. Cavdar2, F. Caglayan1 1Hacettepe University, Ankara, Turkey2Private Practice, Istanbul, Turkey Background The density of newly formed bone is as important as the amount of bone for implant success prior implant placement. Horizontal BIBF-1120 and vertical dimensional bone volume loss occurs after tooth extraction. Preserving and reconstruction of the extraction socket with guided bone regeneration have been suggested to achieve an ideal functional and esthetic prosthetic reconstruction in implant treatments. Aim/Hypothesis The aim of this study is to evaluate bone density changes accordingly computed tomography's (CT) Hounsfield Units (HU) after different socket preservation techniques. Material and methods Seventeen individuals with 52 extraction sockets were investigated in four groups; allogenic graft and collagen membrane (Group 1; N: 14), alloplastic graft and collagen membrane (Group 2; N: 14) and only collagen membrane (Group 3; N: 13). Eleven sockets were left empty as control (Group 4; N: 11). CT scans were taken postoperatively at 10.day and 4.month and intrasocket HU values were measured. Values between and within groups at 10.day and 4.months were compared. Results Postoperative 10.