So How Does SAR1B Perform?

8% had slow total CTT and mean total CTT in patients with functional constipation and IBS-C was 52.2 hours and 41.2 hours, respectively.25 Mollen et al26 showed that 71% of patients with functional constipation had abnormal total CTT, however, patients with IBS had normal colon transit. Actually, previous study showed that only 12% of IBS-C had delayed colon transit. However, in that study, stool form and stool frequency were negatively correlated to total CTT.27 We showed that CTT was not different between patients with functional constipation and those GSK1349572 with IBS-C. A few studies compared the CTT of functionally constipated and IBS-C patients, and showed conflicting data. Two studies showed that the RSCTT was significantly higher in patients with functional constipation than in those with IBS-C.25,28 In our study, patients with functional constipation had a higher RSCTT (18.6 hours) than patients with IBS-C (14.4 hours). However, there was no significant difference between the 2 groups. This study has some limitations as follows: (1) this was a retrospective study with a relatively small sample size. Therefore, we could not show subjects�� individual symptoms or symptom scores. (2) Bowel gas area on plain abdomen radiographs does not constitute an accurate real gas volume. And, SAR1B we adopted a variant method of the original GVS.12 Even though we try to differentiate small bowel gas from colonic gas, redundant transverse colon or sigmoid colon frequently overlaps with small bowel. (3) There was the only small mean difference of colon GVS between the 2 groups. And, ROC curve could not show the diagnostic value of colon GVS in predicting slow transit. Therefore, at the present time, it is difficult to apply to clinical situation on managing constipated patient. For clinical impact on managing constipated patients, the method for measurement of colon GVS need to be more validated and computerized. In summary, there was no correlation between CTT and colon GVS. However, colon GVS in patients with ��CTT �� 45 hours�� was higher than that in patients with ��CTT BMS-354825 order a correlation between the colon GVS and CTT in patients with chronic constipation. However, total colon GVS may be a method of predicting slow transit in patients with chronic constipation. Footnotes Financial support: None. Conflicts of interest: None. Author contributions: Seon-Young Park, planning and/or conducting the study, and drafting the manuscript; Hyun-Bum Park, Ji-Myung Lee, Ho-Jun Lee, Chang-Hwan Park, Hyun-Soo Kim, and Sung-Kyu Choi; and Jong-Sun Rew, in planning the study, revision of the manuscript.""Defining the pathophysiology of chronic constipation is critical for planning management. After excluding organic diseases, physician should speculate whether the constipated patient has a defecatory disorder or not.