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05). Table 1 Characteristics of the cognitively healthy elderly in the Swedish BioFinder study compared with the MDCS re-examination cohort The study population consisted of 208 individuals. The mean (��SD) age at BioFinder study entry was 71.8 (��4.7) years and 59% were women. The mean (��SD) cfPWV was 10.0 (��2.0) m/s. Twenty-five of 207 individuals (12%) had cerebral microbleeds and 65 of 208 (31%) had WMH on MRI. Six individuals (3%) Buparlisib nmr had multiple microbleeds and 10 (5%) had both WMH and microbleeds. Univariate statistical analysis of the study population, grouped by the presence of microbleeds and WMH, is presented in table ?table2.2. Individuals with microbleeds were more often male (p IPI-145 molecular weight with WMH were significantly older (p = 0.001), had higher systolic blood pressure (p = 0.005), higher PWV (p = 0.002) and were more frequently prescribed warfarin (p = 0.005). No other differences between individuals with or without WMH were found (table ?(table22). Table 2 Characteristics of the study population grouped by the presence of cerebral microbleeds (CMB) and WMH Association between cfPWV and Microbleeds or WMH PWV measures were available for 195 individuals with microbleed ratings and 196 with WMH ratings. There was no association between the presence of microbleeds and arterial stiffness in the univariate or adjusted logistic regression models (table ?(table3).3). There was an association between arterial stiffness and WMH in Oxacillin the crude analysis (unadjusted OR, 1.83; 95% CI, 1.24-2.72; p = 0.003). The association was attenuated, but remained significant, after adjustment for age and sex (OR, 1.58; 95% CI, 1.04-2.40; p = 0.03). When further adjustments were made, the association was no longer statistically significant (table ?(table33). Table 3 Association between arterial stiffness and the presence of cerebral microbleeds (CMB) and WMH Cognitive Test Results There was no difference in cognitive performance between individuals with or without microbleeds (table ?(table4).4). Individuals with WMH performed slightly worse than individuals without WMH on the SDMT (mean �� SD; 35 �� 7.8 correct answers vs. 39 �� 8.1 correct answers; p value = 0.049). No other differences between those with or without WMH were found (table ?(table4).4). All models were adjusted for age, sex and years of education. Table 4 Cognitive test results grouped by the presence of cerebral microbleeds (CMB) and WMH Using linear regression models, we found no statistically significant associations between arterial stiffness and different cognitive test results in the study population. All models were adjusted for age, sex and years of education (data not shown).