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Mean scores (with 95% confidence intervals [CI]) and prevalence rates between those who completed the program and those who quit the program were compared at baseline and follow-up, and chi-squares (SPSS Version 23.0) Etoposide price were used to determine statistically significant differences. Those who completed the program and who scored 11 or higher on the BDI-II at baseline were included in an additional analysis. Baseline and follow-up mean BDI-II scores were compared using a paired samples t-test. Further, the group was broken down into two categories: those who no longer had depressed mood at follow-up and those who did. These groups were then compared across demographics, comorbidities, prescription drug use, smoking status, program adherence, self-esteem, self-report health, and self-report mental health using cross-tabulations. Mean scores were compared with 95% confidence intervals reported (P scores were also compared across the two groups. After these initial cross-tabulations, binary logistic regression was used to determine the independent association between the outcome variable of depressed mood at 12 weeks and the potential explanatory variables. In the case where means were statistically significant, scores were grouped into exclusive binary categories. The unadjusted effect of each covariate was determined and then entered one step at a time based on changes in the ?2log likelihood and the Wald test. The final results are presented as adjusted odds ratios with 95% CIs.44 Results HSP90 Participant demographic and baseline information are presented in Table 1. Females, younger participants (Temsirolimus mw differences in baseline mean scores across education level, employment, smoking status, and program completion or adherence (Table 2). Table 1 Participant demographics and baseline information in the Healthy Weights Initiative, N=296 Table 2 Baseline BDI-II scores across demographics and program completion and adherence (lower scores indicate better mood), N=290 Figure 1 indicates the participant data used in this study. Those with missing data were removed from the analysis. The prevalence of depressed mood at baseline among those who completed the program (n=232) was 45.3% (27.2% had mild mood disturbances, 12.1% had borderline clinical depressed mood, 4.7% had moderate depressed mood, and 1.3% had severe or extreme depressed mood). The prevalence of depressed mood at baseline among those who quit the program (n=56) was 46.4% (17.9% had mild mood disturbances, 12.5% had borderline clinical depressed mood, 14.3% had moderate depressed mood, and 1.8% had severe or extreme depressed mood).