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Patients were also compared using the six-point (from 0 to 5) Hoehn and Yahr scale. All 27 typical PD patients were on levodopa and all had responded as determined by a 30% or greater decrease in the motor portion of the MDS-UPDRS. All 27 patients had been evaluated in an ��off�� state 16 hours after their last levodopa dose. All had FOG in their ��off�� state. All were then given a test dose of levodopa up to 200% of their usual dose. They were then evaluated in their ��on�� state. Among the 27 patients, FOG improved in 21 (78%). FOG did not improve in 6 patients (22%). We studied three groups of patients with FOG: a group of 12 atypical parkinsonism patients whose FOG did not respond to levodopa: these patients fell repeatedly (>2 falls per month); a group of 6 typical PD patients whose FOG did not respond to levodopa: these patients fell repeatedly (��2 falls per month); a group of 21 PD patients Unoprostone whose FOG did respond to levodopa: these patients fell less often (��1 fall per month). Although there are anatomical, pathological, and structural differences between the atypical parkinsonism and the typical PD patients, we grouped the 6 typical PD patients whose FOG did not respond to levodopa with the 12 atypical parkinsonism patients whose FOG did not respond to levodopa, consolidating the three groups into two. We then compared these 18 patients to the 21 typical PD patients whose FOG did respond to levodopa (Tables ?(Tables11 and ?and22). Table 1 Demographics of freezing of gait (FOG) patients unresponsive to levodopa Protease Inhibitor Library ic50 compared to those of FOG patients responsive to levodopa. Table BGJ398 concentration 2 Results of postural stability and locomotion tests on freezing of gait (FOG) patients unresponsive to levodopa compared to patients responsive to levodopa. We compared age, disease duration, falls, and step length between both groups using a 2-tailed t-test at the 0.05 level of significance. We compared the five-point Hoehn and Yahr staging system, the five-point FOG subtest, the five-point ��pull subtest,�� the five-point gait subtest, and the ability or inability to stand on one foot for