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3%, 27.5% (22/80) in children without a rash and 56.9% (242/425) in children with a rash. Coxsackievirus A16 positive rate of male (24%, 61/254) was higher than that of female (15.2%, 26/171) (��2?=?4.87, P?=?0.027). The highest positive rate of enterovirus infection was 63.5% in the 2-year-old age group. Comparing children with and without a rash, within the same age groups, no statistical difference was found (P?>?0.05). The seasonal distribution of Enterovirus 71 had only one peak in May, but Coxsackievirus A16 had two peaks in April and October. In patients with a rash, the frequency of Enterovirus 71 was relatively high before July, and then that of Coxsackievirus A16 increased gradually. In the case Mdm2 of Enterovirus 71 and Coxsackievirus A16, stool specimens had a higher positive rate than throat swab specimens' (��2?=?3.88, P?=?0.05; ��2?=?15.13, P?Cyclopamine nmr 2�C3 year-old children, with the implicated virus varying by season. Targeted prevention and control measures should be carried out. J. Med. Virol. 86:1602�C1608, 2014. ? 2014 Wiley Periodicals, Inc. ""The seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV) in Chinese patients with chronic hepatitis B, the relationship between KSHV and hepatitis B virus (HBV) infection, and the influence of glycyrrhizic acid on KSHV replication in vivo are undefined. Plasma was collected from 211 patients with chronic hepatitis B. Antibody to KSHV ORF65 was evaluated by ELISA, and real-time PCR was used to quantify KSHV DNA and HBV DNA. The KSHV ORF65 positivity rate in patients with chronic hepatitis B was found to be 28% (59/211): 27.3% (44/161) in males and 30% (15/50) in females (P?>?0.05). The seroprevalence of KSHV increased with age until reaching the highest rate (37.1%) in the 31�C40 years age group. HBV DNA loads in patients with chronic hepatitis B infected with KSHV were higher than those without KSHV infection (9.2?log (10)?IU/ml vs. 7.8?log (10)?IU/ml, P??0.05). Patients treated with glycyrrhizic acid had lower KSHV DNA levels than www.selleckchem.com/products/sotrastaurin-aeb071.html those without therapy (204.7?copies/ml vs. 533.9?copies/ml, P?
