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Chronic lung diseases other than chronic obstructive pulmonary disease (COPD) included asthma, bronchiectasis, pulmonary fibrosis and old pulmonary tuberculosis [23]. Immunosuppressive therapy was defined as receipt of cytotoxic agents within 6?weeks, or corticosteroids at a dosage equivalent to or higher than 10?mg of prednisolone daily for more than 5?days within 4?weeks prior to the onset of bacteremi A.?Neutropenia was defined as an absolute neutrophil count TRIB1 4?weeks prior to the onset of bacteremi A.?Chronic kidney disease was defined as an estimated glomerular filtration rate (eGFR) Ibrutinib datasheet other than A.?baumannii or A.?nosocomialis from blood during the same bacteraemic episode. The illness severity was evaluated using the Acute Physiology and Chronic Health Evaluation II (APACHE II) score [24] within 24?h prior to bacteraemia onset. Appropriate antimicrobial therapy was defined as administration of at least one antimicrobial agent, to which the causative pathogen was susceptible, within 48?h after the onset of bacteraemia, with an approved route and dosage for end-organ(s) function. Antimicrobial therapy that did not meet this definition was considered as inappropriate. Monotherapy with an aminoglycoside was not considered as an appropriate therapy. The primary outcome measure was all-cause 14-day mortality following the onset of A.?baumannii MK-2206 manufacturer or A.?nosocomialis bacteraemia, respectively. To assess differences, the chi-square test with Yate��s correction or Fisher��s exact test was used to compare the discrete variables; the Student��s t-test or Mann�CWhitney rank sum test was used to analyse continuous variables. Logistic regression models were used to explore independent risk factors for 14-day mortality. Univariate analyses were performed separately for each of the risk factor variables to ascertain the odds ratio (OR) and 95% confidence interval (CI). All biologically plausible variables with a p value of ��0.20 in the univariate analysis were considered for inclusion in the logistic regression model for the multivariate analysis. A backward selection process was utilized. Time to mortality was analysed using Kaplan�CMeier survival analysis. A p value