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However, one study enrolled patients with chronic ITP who had undergone splenectomy; the other included only nonsplenectomized patients who received at least one prior treatment for ITP. Men or women aged 18 years or older with a diagnosis of chronic ITP according to American Society of Hematology guidelines [18] with a platelet count of check details and settings Cefaloridine that allows for easy administration and yields summary values that can be readily incorporated into cost-utility studies [2]. The EQ-5D measures HRQoL on five dimensions (mobility, self care, usual activities, pain/discomfort, and anxiety/depression) and a 20-cm vertical visual analogue scale (VAS) that generates a self rating of HRQoL. Each of the five dimensions contains three levels. Respondents score each dimension, which results in a one-digit number that expresses the level selected (no problems, some problems, extreme problems) for that dimension. All five responses are then combined for a five-digit health state, scored using an algorithm based on a sample from the adult US population to generate preference weights for the health state score [19]. The US-based scoring system was selected because 83% of Proteasome inhibitor the study subjects resided in the US. Higher values for both the health state and VAS scores indicate better HRQoL. Change in the EQ-5D scores from baseline to the last visit (week 25) was a secondary end point in both clinical trials. Patients self-administered the EQ-5D (prior to treatment administration or any clinical procedures) at baseline (week 1) and at weeks 5, 13, and 25 of the treatment period. In both clinical trials, patients who achieved a platelet count of ��50 �� 109/L at any of the scheduled weekly clinic visits without having used rescue medication within 8 weeks on or prior to the visit were defined as having a weekly platelet response. Durable platelet response was defined as having weekly platelet responses for ��6 weeks of the last 8 weeks of treatment of the 24-week treatment period in the absence of rescue medication. When platelet counts drop below 50 �� 109/L, patients may be at increased risk for bleeding [10]. To assess the association of improvement in health utility scores over the course of the 24-week trial with the platelet response status, we compared the change in utility scores in responders versus nonresponders.