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01). The lowest dose of levetiracetam (15?mg) had a smaller effect on AIMs during the first 10 days of treatment and became nonsignificant after the 11th day. These data indicate a dose-dependent effect of levetiracetam on AIMs. Levetiracetam did not interfere with the antiparkinsonian action of L-DOPA. Protease Inhibitor Library concentration Contralateral rotation, a measurement of such an L-Dopa action, increased during the first week of daily L-DOPA treatment and stabilized in the second week with no differences across the control and levetiracetam treatment groups (Figure 1(e)). These behavioral data are aligned with previous reports showing no differences in Parkinsonian motor disability or ��on-time�� effect [14]. These results indicate that levetiracetam effect on AIMs is not related to diminishment in the beneficial antiparkinsonian action of L-DOPA. 3.2. Molecular Effects (Levetiracetam Decreased the BGJ398 Expression of ��FosB and the Phosphorylation of DARPP-32 and ERK1/2 in the Striatum) FosB/��FosB immunoreactive neurons increased in the dorsolateral part of the striatum on the lesion side with the used antibody that recognizes all members of the FosB family. All doses of levetiracetam decreased the number of FosB/��FosB positive cells (from 88.7 �� 1.7/section in the control group to 65.7 �� 0.87, 42.3 �� 1.88, and 25.7 �� 1.2/section in the 15, 30, and 60?mg groups, resp.; Figure 2). These results indicate dose-dependent effects of levetiracetam on FosB/��FosB expression. Figure 2 Levetiracetam-induced changes in FosB/��FosB immunostaining of the dorsolateral portion of the striatum. (a) Images of striatal Unoprostone slices from the lesion side of an animal from each treatment group (control, 15, 30, and 60?mg/kg levetiracetam ... To determine the selective effects of levetiracetam on ��FosB levels, striatal tissue was processed for immunoblotting as well. The striatal expression of ��FosB, the truncated form of FosB, was exaggeratedly higher in the lesioned side compared to the intact side of the striatum after chronic L-DOPA treatment (P