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On physical examination, erythematous macules, vesicles and bullae with an annular configuration were seen on the patient's neck, trunk and proximal limbs (Fig.?1). CHIR-99021 purchase The mucous membranes were not affected. Histopathological examination of the lesion showed a subepidermal blister with dense neutrophilic and eosinophilic infiltration (Fig.?2a). Direct immunofluorescence staining (DIF) found linear deposits of IgA at the basement membrane zone (Fig.?2b). Routine laboratory tests including complete blood count, liver and kidney function tests were normal. Based on the clinical, dermatopatological and immunofluorescence findings, a diagnosis of LABD was made. The patient was prescibed an oral antihistaminic amd topical steroid and the eruptions resolved in 3 weeks. Also, the patient was advised not to use moxifloxacin again. LABD is an autoimmune disorder, characterized by deposition of IgA in the basement membrane zone.[1] LABD can occur in both children and adults.[1] The clinical appearance is of vesicular and bullous eruptions involving the trunk, legs and acral regions.[1, 2] The configuration of the lesions is usually annular, but some patients can have lesions resembling dermatitis herpetiformis, bullous pemphigoid, toxic epidermal necrolysis and bullous erythema multiforme.[2] The eruption of the present case were characteristic of classic LABD. The aetiology of LABD is still not clear, but multiple antigens including the 97?kDa (LABD97), 120?kDa, 180?kDa (BPAG2), 230?kDa (BPAG1), 250?kDa and 280?kDa antigens have Fleroxacin been reported as potential targets for the immune response.[4] A minority of cases of LABD are drug-induced. Vancomycin is the Y 27632 most comon drug associated with LABD. Other associated drugs are penicillin, ceftriaxone, metronidazole, piroxicam, diclofenac, vigabatrin, phenytoin, rifampin, amiodarone, furosemide, lithium carbonate, somatostatin, interferon-�� 2a and atorvastatin.[1-4] Moxifloxacin is a third-generation fluroquinolone antibiotic with Gram-positive activity, which is commonly used for treatment of respiratory tract infections. The incidence of cutaneious adverse reactions, such as pruritus, urticaria and maculopapular exanthems caused by fluroquinolones, is reported as