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Cardiac and valvular disorders have also been described [8]. These cardiovascular (CV) disorders contribute to the high CV morbidity and mortality affecting ADPKD patients. In addition, hypertension is a common symptom of ADPKD that occurs in nearly 60% of patients before deterioration of renal function [9]. Hypertension is associated with rapid progression to ESRD and is also a major CV risk factor [10]. The present article reviews the main characteristics of hypertension in ADPKD patients, including pathophysiological factors and treatment strategies. Arterial hypertension Arterial hypertension is highly prevalent in ADPKD patients compared with patients with other types of renal disease. Nearly 60% of ADPKD patients http://www.selleckchem.com/products/PD-0332991.html have hypertension before any decrease in the glomerular filtration rate [9]. Hypertension occurs earlier and more frequently in PKD1 than in PKD2 and in those ADPKD patients whose affected or unaffected parents also have hypertension [11]. ADPKD children also have a high prevalence of hypertension [12] and data from large registries show that ADPKD children show 4�C6 mmHg higher blood pressure than their age- and sex-matched controls and more frequently a non-dipper profile in the ambulatory blood pressure (BP) monitoring [13] Indeed, this prevalence may be even higher if ambulatory BP monitoring is used to make the diagnosis, owing to the high proportion of masked hypertension Everolimus price in this population [14]. BP monitoring helps Cofactor us to make an early diagnosis of hypertension and to identify non-dipping circadian BP rhythm (