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Dyspnoea was assessed by (Medical Research Council) and modified BORG scales.[11] Exercise capacity was evaluated with 6-min walk test, ISWT and endurance shuttle walk test.[12-14] The minimal clinically important significant differences for the 6-min walk test, ISWT and endurance shuttle Vatalanib (PTK787) 2HCl walk test were: 25�C71?m, 47.5?m and 45�C85?s, respectively.[15] Health status was assessed by the Turkish version of St. George's Respiratory Questionnaire.[16, 17] High score meant a greater impairment in health status. A change of minimal four units from baseline was considered clinically significant. We used Hospital Anxiety and Depression Scale that comprised 14 items to assess depressive symptoms and anxiety. A score equal to or greater than 8 was conventionally used to define anxiety and depression.[18] After measuring body weight and height with shoes off and light clothing, BMI was also calculated as weight (kg)/height square (m2). Fat-free mass was measured with traditional Tanita hand-to-foot bioelectrical impedance analyser (TBF-300, TANITA, Middlesex, UK), with an operating frequency of 50?kHz at 500?Ma. FFMI was in turn calculated as (fat-free mass (kg)/height square (m2)).[10] The CSA of quadriceps femoris was calculated in mid-level of the right thigh over Siemens True D (version VC22B) programme at Siemens Syngo Imaging Suite V35A learn more workstation (Erlangen, Germany).[19] T1-weighted images were collected (time to repetition 550?ms, time to echo 20?ms, field of view 40?cm and matrix 512?��?384 pixels). Patients received three packages of 250-mL nutritional drink consisting of 83.3% energy from carbohydrates, 30% energy from fat and 16.7% energy from proteins per day, and were also encouraged to continue the consumption of their own meal portions. The patients Selleck Docetaxel received dietary advice by the dietitian during visits regarding the content of their meals. The daily intake of the patient was checked by controlling their dietary log. Data were reported as mean?��?standard deviations in the text and tables. The SPSS 20.0 for Windows (IBM Statistics SPSS, Chicago, IL, USA) was used for statistical analysis. One-way analysis of variance and Bonferroni tests were used for comparing the differences between the groups. Changes within the groups were analysed over Wilcoxon rank-sum test. The statistical significance value is P?