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The diagnostic performance of sIgE to predict belonging to subgroup RR was studied by receiver operating characteristic curve analysis. The Youden's index, the indicator that combines the highest positive and negative predictive values [25], was used to select the optimal cut-off. Additionally, a supplementary assessment of baseline risk factors for OIT-related reactions independent of subgroups�� classification was performed, in which risk factors for reactions severity, frequency, and persistence over time on-OIT were evaluated (see additional information in online repository). Succimer PASW Statistics 18 (SPSS Inc., Chicago, IL, USA) was used. A two-tailed P?RSL3 cost at baseline DBPCFC (multisystem reactions including persistent gastrointestinal symptoms in 28 children and lower respiratory tract involvement in 20 children). In active group, 13551 egg-OIT doses were administered. Median time in induction phase was 4.5?months (IQR: 3.7�C6), and median time in maintenance phase was 11?months (IQR: 4.5�C16). The median period on-OIT for safety data collection was 18?months (IQR: 13�C25). The control group was also observed for a median period of 18?months to register accidental reactions (IQR: 13�C21.7, P?=?0.26). There was no loss to follow-up. http://www.selleckchem.com/products/ag-221-enasidenib.html At the end of induction phase, 40 children (80%) had achieved complete desensitization, one child (2%) partial desensitization, and nine cases (18%) had discontinued OIT due to frequent dose-related reactions not improved by medication and protocol re-adaptation (subgroup ED). Subsequently, 12 patients required dose reduction due to dose-related reactions. At 12?months, 28 patients (54%) achieved complete desensitization, whereas 4 (8%) partial desensitization (unresponsiveness to 0.8?g to 1.7?g raw EW protein). Nine more patients discontinued OIT in maintenance phase due to ongoing dose-related reactions (total discontinuation: 18 children -36%; Fig.?1). Five children (15.6%) passed the DBPCFC 12?months after inclusion and 27 (84.4%) still reacted. At 12?months, complete desensitization in active group was more frequent than natural tolerance development in control group (P?