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The majority of these decedents were male (369; 95.8%) and white (341; 88.6%), accounting for 2,064 (95.2%; median: 5.0) and 1,899 (87.6%; median: 5.0) YPLL65, respectively (Table IV). Overall, annual YPLL65 and median YPLL65 attributable to asbestosis did not change significantly over the 1999�C2010 period (Table V). During 1999�C2010, of the 29,639 decedents with malignant mesothelioma coded as the underlying cause of death, 6,209 (20.9%) were aged 25�C64 years (median age at death: 58 see more years) accounting for 53,017 YPLL65 (median per decedent: 7.0 YPLL65). The majority of these decedents were male (4,682; 75.4%) and white (5,701; 91.8%), accounting for 36,818 (69.4%; median: 6.0) and 47,605 (89.8%; median: 6.0) YPLL65, respectively (Table IV). The median YPLL65 for females was significantly greater than that for males (P?C646 research buy Overall, annual YPLL65 and median YPLL65 attributable to mesothelioma did not change significantly over the 1999�C2010 period (Table V). The YPLL is an impact measure that can help quantify the burden of social and economic loss from premature mortality [Gardner and Sanborn, 1990]. The use of premature mortality measures has recently become more common for targeting cancer because it can be used to describe premature death and potential economic loss to the society caused by cancer deaths and also it can enhance the decisions of agencies for evaluating cancer prevention programs [O'Lorcain et al., 2007; Pham et al., 2009; Kamel et al., 2012]. However, information on YPLL attributable to diseases associated with asbestos exposure is limited in the United States. Etomidate Adoption of the ICD-10 for coding death data with a specific code for malignant mesothelioma in 1999 and availability of data for 1999�C2010 provided data to address this gap. This study is the first to report on asbestos-attributable YPLL using national mortality data. We found that deaths attributable to asbestosis and malignant mesothelioma resulted in an annual average of 35,600 YPLL and over 4,600 YPLL65. Nearly 96% of the total YPLL65 attributable to asbestosis and malignant mesothelioma was due to malignant mesothelioma. No significant temporal trend in malignant mesothelioma attributable YPLL or YPLL65 was observed over the years for which data were available. Because the latency period from asbestos exposure to the development of malignant mesothelioma ranges from 20 to 50 years, most malignant mesothelioma occurs at the age of over 45 [CDC, 2008b; Maskell and Millar, 2009]. The majority (85�C87%) of these cases were likely exposed to asbestos at the workplace [Rudd, 2010].