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It might be a source of bias in our tool validity survey. Currently, to the best of our knowledge, this is the first study to show the reliability and validity of the Persian version of SS-QOL. The results of our survey proved that the Persian version of SS-QOL has an efficiently structured specification and convergent validity. In addition, Histone demethylase this instrument can be used for assessing the effects of stroke on the QOL reliably and confidently. Conclusion In conclusion, we may thereby declare to have accomplished the translation, cultural adaptation and testing of reliability and validity of the SS-QOL questionnaire for Iranian patients. Consequently, the Persian version of SS-QOL should be mentioned as a noteworthy instrument to specify different aspects of HR-QOL for patients suffering a stroke and clinicians, researchers and epidemiologist can exploit it trustfully. Acknowledgments We express our sincere gratitude to the patients and their families who are cooperative and collaborative and also all the staff of the Stroke Special Clinic of the Shiraz University of Medical Sciences, Iran. This selleck kinase inhibitor study was supported by Grant No: 2367 from the Vice-Chancellor for Research Affairs of the Shiraz University of Medical Sciences. Conflict of Interests The authors declare no conflict of interest in this study. Notes: How to cite this article: Mahmoodi M, Safari A, Vossoughi M, Golbon-Haghighi F, Kamali-Sarvestani M, Ghaem H, et al. Stroke specific quality of life questionnaire: test of reliability and validity of the Persian version. Iran J Neurol 2015; 14(2): 94-100.""Background: Non motor symptoms (NMS) of idiopathic Parkinson��s disease (PD) are a major cause of disability and recognition of these symptoms and treatment is important for comprehensive health care. Deep brain stimulation of bilateral subthalamic nucleus deep brain stimulation (STN DBS) Selleckchem Enzalutamide has been shown to improve motor symptoms in PD and effects on NMS are unknown. To investigate the NMS among PD patients who underwent STN DBS. Methods: We recruited prospectively 56 patients with PD, who had undergone bilateral STN DBS and 53 age and duration of illness matched PD patients on dopaminergic therapy (controls). NMS were assessed using 30 item questionnaire NMS Quest. These questions evaluated 9 domains, gastrointestinal, urinary, cardiovascular, sexual, cognition (apathy/attention/memory), anxiety/depression, hallucinations/delusions, sleep and miscellaneous. Comparison was done on individual symptoms as well as in various domains. This study was carried at Nizam��s Institution of Medical Sciences and study period was from January 2011 to December 2012. Results: Patients who underwent STN DBS had a significantly lower mean total score on NMS quest (6.7 �� 3.8) compared to controls (8.4 �� 3.7) (P