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We Cobimetinib order describe here the detailed epidemiology, management and prognosis in the subgroup of patients with Candida peritonitis. AmarCand�� was a prospective, multicentre, French observational study involving adult ICU patients with invasive Candida infection requiring a systemic antifungal therapy [11]. Criteria used for diagnosis were those proposed by the Invasive Fungal Infection Group of the European Organization for Research and Treatment of Cancer [12]. In accordance with French law, approval of an ethics committee was not required. However, all patients gave informed consent to participate and procedures were in accordance with the Helsinki Declaration. A scientific committee (the authors) independently designed the study, and reviewed the data. For each episode of Candida peritonitis, demographic characteristics, underlying diseases and severity of illness were compared with the other patients in the Amarcand cohort. Empiric antifungal treatment, interventions associated with antifungal treatment and risk factors for death were assessed in cases of Candida peritonitis [11]. Peritonitis was diagnosed on the basis see more of macroscopic findings and direct examination or positive culture for Candida of the peritoneal fluid collected during operation. Candidaemia was defined by at least one positive blood culture. Candida peritonitis was considered as nosocomial if diagnosed ��48?h after hospitalization or community-acquired (ALG1 variables. Groups were compared using the Wilcoxon, chi-square or Fisher��s exact tests where appropriate. Statistical significance was accepted at the 5% level. Among the 271 patients recruited between October 2005 and May 2006 in the ��AmarCand�� cohort [11], the present study focused on the 93 evaluable patients treated for nosocomial peritonitis (n?=?73) and community-acquired peritonitis (n?=?20). The clinical characteristics of these patients with Candida peritonitis were compared with those of the remaining 178 patients without peritonitis.